Characterization of Five Zoonotic Streptococcus suis Strains from Germany, Including One Isolate from a Recent Fatal Case of Streptococcal Toxic Shock-Like Syndrome in a Hunter

Tobias Eisenberg; Christoph Hudemann; Hamid M Hossain; Angela Hewer; Khodr Tello; Dirk Bandorski; Manfred Rohde; Peter Valentin-Weigand; Christoph Georg Baums

doi:10.1128/JCM.02578-15

Characterization of Five Zoonotic Streptococcus suis Strains from Germany, Including One Isolate from a Recent Fatal Case of Streptococcal Toxic Shock-Like Syndrome in a Hunter

J Clin Microbiol. 2015 Dec;53(12):3912-5. doi: 10.1128/JCM.02578-15. Epub 2015 Sep 30.

Authors

Tobias Eisenberg¹, Christoph Hudemann², Hamid M Hossain³, Angela Hewer¹, Khodr Tello⁴, Dirk Bandorski⁴, Manfred Rohde⁵, Peter Valentin-Weigand⁶, Christoph Georg Baums⁷

Affiliations

¹ Hessian State Laboratory, Department of Veterinary Medicine, Giessen, Germany.
² Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany.
³ Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany.
⁴ Medical Clinic II, Justus Liebig University Giessen, Gissen, Germany.
⁵ Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany.
⁶ Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany.
⁷ Institute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany Institute for Bacteriology and Mycology, Centre of Infectious Diseases, College of Veterinary Medicine, University Leipzig, Leipzig, Germany christoph.baums@vetmed.uni-leipzig.de.

Abstract

A Streptococcus suis isolate from a German hunter with streptococcal toxic shock-like syndrome (STSLS) and four additional zoonotic isolates were genotyped as mrp(+) epf* (variant 1890) sly(+) cps2(+). All five zoonotic German strains were characterized by high multiplication in human blood samples ex vivo, but induction of only low levels of proinflammatory cytokines compared to a Chinese STSLS strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines / metabolism
Genotype*
Germany
Humans
Shock, Septic / microbiology
Streptococcal Infections / microbiology*
Streptococcal Infections / veterinary*
Streptococcus suis / classification*
Streptococcus suis / genetics*
Streptococcus suis / growth & development
Streptococcus suis / isolation & purification

Substances

Cytokines