Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Lin Sun; Yashpal S Kanwar

doi:10.1038/ki.2015.250

Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Kidney Int. 2015 Oct;88(4):662-5. doi: 10.1038/ki.2015.250.

Authors

Lin Sun¹, Yashpal S Kanwar^{2

3}

Affiliations

¹ Department of Nephrology and Renal Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Pathology, Northwestern University, Chicago, Illinois, USA.
³ Department of Medicine, Northwestern University, Chicago, Illinois, USA.

Abstract

An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Diabetic Nephropathies / metabolism*
Inflammation Mediators / metabolism*
Kidney / metabolism*
Macrophages, Peritoneal / metabolism*
Male
Tumor Necrosis Factor-alpha / metabolism*

Substances

Inflammation Mediators
Tumor Necrosis Factor-alpha

Abstract

Publication types

MeSH terms

Substances

Grants and funding