Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

Roya Tavallaie; Nadim Darwish; D Brynn Hibbert; J Justin Gooding

doi:10.1039/c5cc05450h

Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

Chem Commun (Camb). 2015 Nov 28;51(92):16526-9. doi: 10.1039/c5cc05450h.

Authors

Roya Tavallaie¹, Nadim Darwish², D Brynn Hibbert², J Justin Gooding¹

Affiliations

¹ School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia. Justin.gooding@unsw.edu.au and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, NSW 2052, Australia.
² School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia. Justin.gooding@unsw.edu.au.

PMID: 26419208
DOI: 10.1039/c5cc05450h

Abstract

The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / standards*
Nucleic Acids / chemistry*
RNA / chemistry*

Substances

Nucleic Acids
RNA