Abstract
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
Keywords:
Anticancer activity; Juglans mandshurica; Juglanstetralone A; Juglanstetralone B; Walnut husk.
Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Carcinoma / drug therapy*
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Cell Line, Tumor
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Humans
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Juglans / chemistry*
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Naphthols / isolation & purification
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Naphthols / pharmacology
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Naphthols / therapeutic use*
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Nuts / chemistry*
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Stomach Neoplasms / drug therapy*
Substances
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4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
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4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
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Antineoplastic Agents, Phytogenic
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Naphthols
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Plant Extracts