Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities

Chin J Nat Med. 2015 Sep;13(9):707-10. doi: 10.1016/S1875-5364(15)30070-4.

Abstract

Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).

Keywords: Anticancer activity; Juglans mandshurica; Juglanstetralone A; Juglanstetralone B; Walnut husk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Carcinoma / drug therapy*
  • Cell Line, Tumor
  • Humans
  • Juglans / chemistry*
  • Naphthols / isolation & purification
  • Naphthols / pharmacology
  • Naphthols / therapeutic use*
  • Nuts / chemistry*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Stomach Neoplasms / drug therapy*

Substances

  • 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
  • 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
  • Antineoplastic Agents, Phytogenic
  • Naphthols
  • Plant Extracts