135 patients with chronic uveitis were observed and 23 had therapeutic problems by their severity. The corticoid treatment method, always used in a first time, is studied. When there is corticoresistance, corticodependance or absolute contra-indications, the immunosuppressive drugs are used with reduced doses to avoid an AIDS. The corticoid bolus, the plasma exchange and colchicine are adjuvant treatments. Cyclosporin A brings large hopes but its use is now limited by necessity and serious side effects. Serious uveitis does not answer to a unique therapeutic protocol. The treatment must be adaptable and surgery decided in time.