Background: Because medical personnel share different work shifts (i.e., three work shifts) and do not have a fixed work schedule, implementing timely, flexible, and quick e-learning methods for their continued education is imperative. Hospitals are currently focusing on developing e-learning.
Objective: This study aims to explore the key factors that influence the effectiveness of e-learning in medical personnel.
Methods: This study recruited medical personnel as the study participants and collected sample data by using the questionnaire survey method.
Results: This study is based on the information systems success model (IS success model), a significant model in MIS research. This study found that the factors (i.e., information quality, service quality, convenience, and learning climate) influence the e-learning satisfaction and in turn influence effectiveness in medical personnel.
Conclusions: This study provided recommendations to medical institutions according to the derived findings, which can be used as a reference when establishing e-learning systems in the future.
Keywords: E-learning; IS success model; e-learning effectiveness; e-learning satisfaction.