Abstract
Invasive fungal infection (IFI) is an important cause of mortality in immunocompromised children, particularly after hematopoietic stem cell transplantation. We describe 5 cases of Fusarium IFI in immunocompromised children seen at our institution over a 15-year period. A summary of all published pediatric cases of invasive Fusarium infection is presented. A focus on antifungal management challenges in these patients will be discussed.
Keywords:
Fusarium; children; hematopoietic stem cell transplantation; immunocompromised host; invasive fungal infection.
© The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
MeSH terms
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Adolescent
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Antifungal Agents / therapeutic use*
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Brain / drug effects
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Brain / microbiology
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Brain / physiopathology
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Canada
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Child
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Child, Preschool
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Coinfection
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Drug Therapy, Combination / adverse effects
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Drug Therapy, Combination / methods*
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Female
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Fusariosis / complications
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Fusariosis / drug therapy*
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Fusariosis / mortality*
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Fusarium / drug effects
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Fusarium / pathogenicity
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Hematopoietic Stem Cell Transplantation / adverse effects
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Humans
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Immunocompromised Host
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Infant
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Liver / drug effects
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Liver / microbiology
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Liver / physiopathology
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Lung / drug effects
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Lung / microbiology
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Lung / physiopathology
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Male
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Neutropenia / drug therapy
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Neutropenia / microbiology
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Paranasal Sinuses / drug effects
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Paranasal Sinuses / microbiology
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Paranasal Sinuses / physiopathology
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Skin / drug effects
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Skin / microbiology
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Skin / physiopathology