Abstract
We report a 66% reduction in neonatal tetanus mortality after introducing a new management bundle integrating antibiotic therapy, muscle relaxation and invasive monitoring. The latter allowed rapid detection of autonomic instability which was treated with magnesium sulphate. This is the first report of its use in neonatal tetanus.
Keywords:
autonomic dysfunction; magnesium sulfate; neonatal tetanus.
© The Author 2015. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Blood Pressure Determination
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Critical Care / methods*
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Humans
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Hypnotics and Sedatives / therapeutic use
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Infant, Newborn
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Magnesium Sulfate / therapeutic use
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Monitoring, Physiologic / methods
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Neuromuscular Agents / therapeutic use
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Positive-Pressure Respiration
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Retrospective Studies
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Tetanus / drug therapy
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Tetanus / mortality*
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Tetanus / therapy*
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Vietnam / epidemiology
Substances
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Anti-Bacterial Agents
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Hypnotics and Sedatives
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Neuromuscular Agents
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Magnesium Sulfate