Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Nicolle H Rekers; Catharina Ml Zegers; Wilfred Tv Germeraad; Ludwig Dubois; Philippe Lambin

doi:10.1080/2162402X.2015.1021541

Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Oncoimmunology. 2015 Apr 2;4(8):e1021541. doi: 10.1080/2162402X.2015.1021541. eCollection 2015 Aug.

Authors

Nicolle H Rekers¹, Catharina Ml Zegers¹, Wilfred Tv Germeraad², Ludwig Dubois¹, Philippe Lambin¹

Affiliations

¹ Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.
² Department of Internal Medicine GROW; School for Oncology and Developmental Biology; Maastricht University Medical Centre ; Maastricht, The Netherlands.

Abstract

Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

Keywords: ED-B; cytotoxic T cells; immune response; immunotherapy.