Pituitary adenomas are benign tumors that arise within the anterior lobe (the adenohypophysis) of the pituitary gland in the sella turcica. As they grow, they can extend through the pituitary stalk and into the suprasellar compartment. The surgical management of these adenomas via a conventional intradural approach is fraught with a high risk of causing a large cerebrospinal fluid leak. We report a case of pituitary adenoma in a 60-year-old woman whose surgery was performed via a minimally invasive endoscopic transnasal transsphenoidal transtuberculum sellae extradural approach.