Crystal structure of 3-amino-2-propyl-quinazolin-4(3H)-one

Gamal A El-Hiti; Keith Smith; Amany S Hegazy; Saud A Alanazi; Benson M Kariuki

doi:10.1107/S2056989015013134

Crystal structure of 3-amino-2-propyl-quinazolin-4(3H)-one

Acta Crystallogr E Crystallogr Commun. 2015 Jul 22;71(Pt 8):o590-1. doi: 10.1107/S2056989015013134. eCollection 2015 Aug 1.

Authors

Gamal A El-Hiti¹, Keith Smith², Amany S Hegazy², Saud A Alanazi¹, Benson M Kariuki²

Affiliations

¹ Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia.
² School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, Wales.

Abstract

In the title mol-ecule, C11H13N3O, the propyl group is almost perpendicular to the quinazolin-4(3H)-one mean plane, making a dihedral angle of 88.98 (9)°. In the crystal, mol-ecules related by an inversion centre are paired via π-π overlap, indicated by the short distances of 3.616 (5) and 3.619 (5) Å between the centroids of the aromatic rings of neighbouring mol-ecules. Inter-molecular N-H⋯N and N-H⋯O hydrogen bonds form R 6 (6)(30) rings and C(5) chains, respectively, generating a three-dimensional network. Weak C-H⋯O inter-actions are also observed.

Keywords: crystal structure; hydrogen bonding; quinazolin-4(3H)-one; π–π overlap.