Antibiotic therapy and Clostridium difficile infection - primum non nocere - first do no harm

Grace S Crowther; Mark H Wilcox

doi:10.2147/IDR.S87224

Antibiotic therapy and Clostridium difficile infection - primum non nocere - first do no harm

Infect Drug Resist. 2015 Sep 15:8:333-7. doi: 10.2147/IDR.S87224. eCollection 2015.

Authors

Grace S Crowther¹, Mark H Wilcox²

Affiliations

¹ Faculty of Medicine and Health, University of Leeds, Leeds, UK.
² Faculty of Medicine and Health, University of Leeds, Leeds, UK ; Department of Microbiology, Leeds Teaching Hospitals Trust, Leeds, UK.

Abstract

Treatment options for Clostridium difficile infection (CDI) remain limited despite this usually nosocomial infection posing an urgent threat to public health. A major paradox of the management of CDI is the use of antimicrobial agents to treat infection, which runs the risk of prolonged gut microbiota perturbation and so recurrence of infection. Here, we explore alternative CDI treatment and prevention options currently available or in development. Notably, strategies that aim to reduce the negative effects of antibiotics on gut microbiota offer the potential to alter current antimicrobial stewardship approaches to preventing CDI.

Keywords: CDI; SYN-004; beta-lactams; prevention; treatment; vaccine.