Improving the (18)F-fluoromethylcholine ((18)F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added (18)F-fluorine

Hishar Hassan; Suharzelim Abu Bakar; Khairul Najah Che A Halim; Jaleezah Idris; Fathinul Fikri Ahmad Saad; Abdul Jalil Nordin

doi:10.1002/jlcr.3347

Improving the (18)F-fluoromethylcholine ((18)F-FCH) radiochemical yield via optimising the azeotropic drying of non-carrier-added (18)F-fluorine

J Labelled Comp Radiopharm. 2015 Sep-Oct;58(11-12):458-9. doi: 10.1002/jlcr.3347. Epub 2015 Sep 23.

Authors

Hishar Hassan¹, Suharzelim Abu Bakar², Khairul Najah Che A Halim², Jaleezah Idris², Fathinul Fikri Ahmad Saad¹, Abdul Jalil Nordin¹

Affiliations

¹ Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Serdang, Malaysia.
² National Cancer Institute, Putrajaya, Malaysia.

PMID: 26395258
DOI: 10.1002/jlcr.3347

Abstract

(18)F-Fluoromethylcholine ((18)F-FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with (18)F-FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved (18)F-FCH radiochemical yields after carrying out optimisation on azeotropic drying of non-carrier-added (18)F-Fluorine.

Keywords: F-18 Fluorocholine; azeotropic drying; quality control analysis; radiochemical yield.

MeSH terms

Chemistry Techniques, Synthetic / instrumentation
Chemistry Techniques, Synthetic / methods*
Choline / analogs & derivatives*
Choline / chemical synthesis
Desiccation / instrumentation
Desiccation / methods*
Fluorine Radioisotopes / chemistry
Radiopharmaceuticals / chemical synthesis*

Substances

Fluorine Radioisotopes
Radiopharmaceuticals
fluorocholine
Choline