Limonoids from Munronia henryi and their anti-tobacco mosaic virus activity

Fitoterapia. 2015 Dec:107:29-35. doi: 10.1016/j.fitote.2015.09.016. Epub 2015 Sep 18.

Abstract

Five new compounds (1-5), including three limonoids, one diterpenoid, and one phytosterol, along with four known limonoids (6-9), were isolated from the ethanolic extracts of whole plants of Munronia henryi. Their structures were elucidated by extensive spectroscopic analysis. In addition, the anti-tobacco mosaic virus (TMV) activities of all the isolated compounds were evaluated by the conventional half-leaf and leaf-disk methods along with Western blot analysis. Most of the tested compounds showed strong antiviral activities, with IC50 values in the range of 14.8-34.0μg/mL, compared with ningnanmycin as a positive control (IC50=44.6μg/mL), and their preliminary structure-activity relationships were also discussed.

Keywords: Anti-tobacco mosaic virus (TMV) activity; Limonoids; Munronia henryi; Structure-activity relationship; Western blot.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Limonins / chemistry*
  • Limonins / isolation & purification
  • Meliaceae / chemistry*
  • Molecular Structure
  • Phytosterols / chemistry
  • Phytosterols / isolation & purification
  • Plant Extracts / chemistry
  • Structure-Activity Relationship
  • Tobacco Mosaic Virus / drug effects

Substances

  • Antiviral Agents
  • Diterpenes
  • Limonins
  • Phytosterols
  • Plant Extracts