Role of nerve growth factor and tropomyosin receptor kinase A in the pathogenesis of osteoarthritis. Might nerve growth factor be the link interwinding obesity and osteoarthritis?

Ann Rheum Dis. 2015 Dec;74(12):e70. doi: 10.1136/annrheumdis-2015-208519. Epub 2015 Sep 18.
No abstract available

Keywords: Disease Activity; Osteoarthritis; Treatment.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Arthralgia / drug therapy*
  • Body Mass Index
  • Cartilage / metabolism
  • Chondrocytes / metabolism
  • Disease Models, Animal
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factors / antagonists & inhibitors*
  • Nerve Growth Factors / metabolism
  • Osteoarthritis / drug therapy*
  • Osteoarthritis / metabolism
  • RNA, Messenger / metabolism
  • Rats
  • Receptor, trkA / antagonists & inhibitors*
  • Receptor, trkA / metabolism
  • Synovitis / drug therapy

Substances

  • Nerve Growth Factors
  • RNA, Messenger
  • Receptor, trkA