Can ficolin-2 (L-ficolin) insufficiency be established by a single serum protein measurement?

D C Kilpatrick; A S Świerzko; M Sobociński; W Krajewski; K Chojnacka; J Szczapa; M Cedzyński

doi:10.1111/iji.12229

Can ficolin-2 (L-ficolin) insufficiency be established by a single serum protein measurement?

Int J Immunogenet. 2015 Dec;42(6):453-6. doi: 10.1111/iji.12229. Epub 2015 Sep 18.

Authors

D C Kilpatrick¹, A S Świerzko², M Sobociński³, W Krajewski³, K Chojnacka⁴, J Szczapa⁴, M Cedzyński²

Affiliations

¹ Scottish National Blood Transfusion Service, National Science Laboratory, Edinburgh, UK.
² Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
³ Department of Anesthesiology and Intensive Therapy, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
⁴ Department of Newborns' Infectious Diseases, Poznan University of Medical Sciences, Poznan, Poland.

PMID: 26385254
DOI: 10.1111/iji.12229

Abstract

Serum ficolin-2 was measured in multiple (2-27) samples from 68 paediatric sepsis patients. Fourteen individuals (21%) gave values that included a change in status from 'normal' to 'insufficient' or vice versa. Therefore, if possible, ficolin-2 concentration should be determined in samples obtained when a disease is inactive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Child, Preschool
Female
Ficolins
Humans
Infant
Infant, Newborn
Lectins / blood*
Male
Reproducibility of Results
Sepsis / blood
Sepsis / diagnosis
Sepsis / genetics

Substances

Biomarkers
Lectins