Evidence of slow Debye-like relaxation in the anti-inflammatory agent etoricoxib

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Aug;92(2):022309. doi: 10.1103/PhysRevE.92.022309. Epub 2015 Aug 25.

Abstract

The origin of Debye-like relaxation in some hydrogen-bonded liquids is a matter of hot debate over the past decade. While a relatively clear picture of the issue has been established for monohydroxy alcohols, the Debye-type dynamics in other glass-forming systems still remains a not fully understood phenomenon. In this paper we present the results of dielectric measurements performed in the frequency interval 10(-1) to 10(9)Hz, both in the supercooled and normal liquid state of etoricoxib anti-inflammatory agent. Our investigations reveal the presence of slow Debye-like relaxation with features similar to that found for another active pharmaceutical ingredient, ibuprofen. Our results provide a fresh insight into the molecular nature of Debye-type relaxation in H-bonded pharmaceutically relevant materials and thus may stimulate the academic community for further discussion concerning the molecular dynamics of hydrogen-bonded fluids in general.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Computer Simulation
  • Cyclooxygenase 2 Inhibitors / chemistry*
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Dielectric Spectroscopy
  • Etoricoxib
  • Hydrogen Bonding
  • Ibuprofen / chemistry
  • Ibuprofen / pharmacology
  • Models, Chemical
  • Protons
  • Pyridines / chemistry*
  • Pyridines / pharmacology
  • Sulfones / chemistry*
  • Sulfones / pharmacology
  • Temperature

Substances

  • Cyclooxygenase 2 Inhibitors
  • Protons
  • Pyridines
  • Sulfones
  • Ibuprofen
  • Etoricoxib