De novo peroxisome biogenesis: Evolving concepts and conundrums

Biochim Biophys Acta. 2016 May;1863(5):892-901. doi: 10.1016/j.bbamcr.2015.09.014. Epub 2015 Sep 14.

Abstract

Peroxisomes proliferate by growth and division of pre-existing peroxisomes or could arise de novo. Though the de novo pathway of peroxisome biogenesis is a more recent discovery, several studies have highlighted key mechanistic details of the pathway. The endoplasmic reticulum (ER) is the primary source of lipids and proteins for the newly-formed peroxisomes. More recently, an intricate sorting process functioning at the ER has been proposed, that segregates specific PMPs first to peroxisome-specific ER domains (pER) and then assembles PMPs selectively into distinct pre-peroxisomal vesicles (ppVs) that later fuse to form import-competent peroxisomes. In addition, plausible roles of the three key peroxins Pex3, Pex16 and Pex19, which are also central to the growth and division pathway, have been suggested in the de novo process. In this review, we discuss key developments and highlight the unexplored avenues in de novo peroxisome biogenesis.

Keywords: De novo peroxisome biogenesis; Intra-ER sorting, import of PMPs into the ER, growth and division vs de novo peroxisome biogenesis; Pre-peroxisomal vesicles, ppVs; Pre-peroxisomal-ER, pER; Role of endoplasmic reticulum in peroxisome biogenesis, peroxisomal membrane protein biogenesis; Role of the endoplasmic reticulum in yeast, mammals and plants.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / chemistry
  • Endoplasmic Reticulum / metabolism*
  • Eukaryotic Cells / chemistry
  • Eukaryotic Cells / metabolism
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Organelle Biogenesis*
  • Peroxins
  • Peroxisomes / chemistry
  • Peroxisomes / metabolism*
  • Plants / chemistry
  • Plants / metabolism
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary
  • Protein Transport
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Signal Transduction
  • Yeasts / chemistry
  • Yeasts / metabolism

Substances

  • Fungal Proteins
  • Membrane Proteins
  • PEX16 protein, Yarrowia lipolytica
  • PEX19 protein, S cerevisiae
  • PEX3 protein, S cerevisiae
  • Peroxins
  • Protein Isoforms
  • Saccharomyces cerevisiae Proteins