Abstract
Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy. Inhibitors of mycotoxin production are useful not only for developing effective methods to prevent mycotoxin contamination, but also for investigating the molecular mechanisms of secondary metabolite production by fungi. We have been searching for mycotoxin production inhibitors among natural products and investigating their modes of action. In this article, we review aflatoxin and trichothecene production inhibitors, including our works on blasticidin S, methyl syringate, cyclo(L-Ala-L-Pro), respiration inhibitors, and precocene II.
Keywords:
aflatoxin; biocontrol; mycotoxin; precocene; trichothecene.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aflatoxins / antagonists & inhibitors*
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Aflatoxins / biosynthesis
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Aspergillus / drug effects*
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Aspergillus / pathogenicity
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Aspergillus / physiology
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Benzopyrans / pharmacology
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Crops, Agricultural / drug effects
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Crops, Agricultural / microbiology
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Food Contamination / prevention & control*
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Fungicides, Industrial / pharmacology*
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Fusarium / drug effects*
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Fusarium / pathogenicity
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Fusarium / physiology
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Gallic Acid / analogs & derivatives
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Gallic Acid / pharmacology
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Humans
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Nucleosides / pharmacology
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Oils, Volatile / chemistry
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Oils, Volatile / pharmacology
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Peptides, Cyclic / pharmacology
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Plant Diseases / microbiology
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Structure-Activity Relationship
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Trichothecenes / antagonists & inhibitors*
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Trichothecenes / biosynthesis
Substances
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Aflatoxins
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Benzopyrans
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Fungicides, Industrial
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Nucleosides
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Oils, Volatile
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Peptides, Cyclic
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Trichothecenes
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methyl syringate
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precocene II
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Gallic Acid
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blasticidin S