1 Mental Health and Wellbeing, University of Glasgow, Admin Building, Gartnavel Royal Hospital, Glasgow, Scotland, United Kingdom Department of Pathophysiology and Transplantation, Milan University, Milano, Italy, and Neuroscience ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium Usher Institute of Population Health Sciences and Informatics, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.