Using human genetics to make new medicines

Jeffrey C Barrett; Ian Dunham; Ewan Birney

doi:10.1038/nrg3998

Using human genetics to make new medicines

Nat Rev Genet. 2015 Oct;16(10):561-2. doi: 10.1038/nrg3998. Epub 2015 Sep 15.

Authors

Jeffrey C Barrett^{1

2

3}, Ian Dunham^{1

2

3}, Ewan Birney³

Affiliations

¹ Centre for Therapeutic Target Validation.
² Wellcome Trust Sanger Institute.
³ European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

PMID: 26370900
DOI: 10.1038/nrg3998

Abstract

Jeffrey Barrett, Ian Dunham and Ewan Birney discuss the initiatives of the newly founded Centre for Therapeutic Target Validation, including a range of approaches to use human genetics to inform drug discovery and make better medicines.

MeSH terms

Clustered Regularly Interspaced Short Palindromic Repeats
Crohn Disease / genetics
Drug Discovery / methods*
Genetic Variation
Genetics, Medical / methods*
Genome-Wide Association Study
Humans
Hydroxymethylglutaryl CoA Reductases / genetics
International Cooperation
Smad7 Protein / genetics

Substances

SMAD7 protein, human
Smad7 Protein
HMGCR protein, human
Hydroxymethylglutaryl CoA Reductases