In Vitro Susceptibility Profiles of Eight Antifungal Drugs against Clinical and Environmental Strains of Phaeoacremonium

Hamid Badali; Sadegh Khodavaisy; Hamed Fakhim; G Sybren de Hoog; Jacques F Meis; Anuradha Chowdhary

doi:10.1128/AAC.01733-15

In Vitro Susceptibility Profiles of Eight Antifungal Drugs against Clinical and Environmental Strains of Phaeoacremonium

Antimicrob Agents Chemother. 2015 Dec;59(12):7818-22. doi: 10.1128/AAC.01733-15. Epub 2015 Sep 14.

Authors

Hamid Badali¹, Sadegh Khodavaisy², Hamed Fakhim³, G Sybren de Hoog⁴, Jacques F Meis⁵, Anuradha Chowdhary⁶

Affiliations

¹ Department of Medical Mycology and Parasitology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
² Department of Medical Parasitology and Mycology, Kurdistan University of Medical Sciences, Sanandaj, Iran Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran.
³ Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
⁵ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands j.meis@cwz.nl.
⁶ Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

Abstract

In vitro susceptibilities of a worldwide collection of molecularly identified Phaeoacremonium strains (n = 43) belonging to seven species and originating from human and environmental sources were determined for eight antifungal drugs. Voriconazole had the lowest geometric mean MIC (0.35 μg/ml), followed by posaconazole (0.37 μg/ml), amphotericin B (0.4 μg/ml), and isavuconazole (1.16 μg/ml). Caspofungin, anidulafungin, fluconazole, and itraconazole had no activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology*
Anidulafungin
Antifungal Agents / pharmacology*
Ascomycota / drug effects*
Ascomycota / growth & development
Ascomycota / isolation & purification
Caspofungin
Echinocandins / pharmacology
Fluconazole / pharmacology
Humans
Itraconazole / pharmacology
Lipopeptides / pharmacology
Microbial Sensitivity Tests
Mycoses / microbiology
Nitriles / pharmacology*
Pyridines / pharmacology*
Triazoles / pharmacology*
Voriconazole / pharmacology*

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Nitriles
Pyridines
Triazoles
Itraconazole
isavuconazole
posaconazole
Amphotericin B
Fluconazole
Anidulafungin
Caspofungin
Voriconazole