Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

Eduardo P Amaral; Elena B Lasunskaia; Maria Regina D'Império-Lima

doi:10.1016/j.micinf.2015.09.005

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

Microbes Infect. 2016 Jan;18(1):11-20. doi: 10.1016/j.micinf.2015.09.005. Epub 2015 Sep 11.

Authors

Eduardo P Amaral¹, Elena B Lasunskaia², Maria Regina D'Império-Lima³

Affiliations

¹ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: eduardoamaral@usp.br.
² Laboratory of Recognition Biology, Center of Biosciences and Biotechnology, State University of North Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil.
³ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: relima@usp.br.

PMID: 26369715
DOI: 10.1016/j.micinf.2015.09.005

Abstract

The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the cell death pathways in infected macrophages and, consequently, the pathogenesis of tuberculosis.

Keywords: Cell death; Danger signal; Inflammatory mediators; Innate immune sensors; Mycobacteria.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Death*
Host-Pathogen Interactions
Humans
Immunity, Innate*
Macrophages / immunology*
Macrophages / physiology*
Mycobacterium tuberculosis / immunology*
Mycobacterium tuberculosis / pathogenicity*
Tuberculosis / pathology*