Merosesquiterpenoids and ten-membered macrolides from a soft coral-derived Lophiostoma sp. fungus

Chem Biodivers. 2015 Sep;12(9):1407-14. doi: 10.1002/cbdv.201400331.

Abstract

One new merosesquiterpenoid, craterellin D (1), along with one known analog, craterellin A (2), and five known ten-membered macrolides, 3-7, were isolated from a soft coral-derived Lophiostoma sp. fungus. The absolute configuration of 1 was established based on biogenetic consideration with the co-isolated analog 2, whose configuration was determined by modified Mosher's method and single-crystal X-ray diffraction analysis using CuKα radiation. The absolute configuration of 3 was determined by X-ray diffraction analysis using CuKα radiation. Compounds 2 and 3 showed antibacterial activities against Bacillus cereus with a MIC value of 3.12 μM.

Keywords: Antibacterial activity; Lophiostoma; Macrolides; Merosesquiterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / microbiology*
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Ascomycota / chemistry*
  • Bacillus cereus / drug effects
  • Crystallography, X-Ray
  • Macrolides / chemistry*
  • Macrolides / isolation & purification
  • Macrolides / pharmacology
  • Models, Molecular
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Sesquiterpenes