Nutrient Competition: A New Axis of Tumor Immunosuppression

Cell. 2015 Sep 10;162(6):1206-8. doi: 10.1016/j.cell.2015.08.064.

Abstract

It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.

Publication types

  • Comment

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism*
  • Glycolysis*
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Lymphocytes, Tumor-Infiltrating / metabolism*
  • Melanoma / immunology*
  • Melanoma / therapy*
  • Monitoring, Immunologic*
  • Neoplasms / metabolism*
  • Phosphoenolpyruvate / metabolism*
  • Tumor Microenvironment*

Substances

  • Phosphoenolpyruvate