Abstract
It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
Copyright © 2015 Elsevier Inc. All rights reserved.
MeSH terms
-
Animals
-
CD4-Positive T-Lymphocytes / immunology*
-
CD8-Positive T-Lymphocytes / metabolism*
-
Glycolysis*
-
Lymphocytes, Tumor-Infiltrating / immunology*
-
Lymphocytes, Tumor-Infiltrating / metabolism*
-
Melanoma / immunology*
-
Melanoma / therapy*
-
Monitoring, Immunologic*
-
Neoplasms / metabolism*
-
Phosphoenolpyruvate / metabolism*
-
Tumor Microenvironment*