The efficacy of intrauterine injection of human chorionic gonadotropin before embryo transfer in assisted reproductive cycles: Meta-analysis

J Int Med Res. 2015 Dec;43(6):738-46. doi: 10.1177/0300060515592903. Epub 2015 Sep 10.

Abstract

Objectives: A systematic review and meta-analysis to evaluate the effect of human chorionic gonadotropin (hCG) intrauterine injection before embryo transfer on the outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).

Methods: Searches of PubMed®, EMBASE®, EBSCO, Web of Science®, SCOPUS® and Cochrane Central Register of Controlled Trials were conducted to retrieve relevant randomized controlled trials (RCTs). Data were extracted and analysed.

Results: The meta-analysis included five RCTs (hCG group n = 680; control group n = 707). Intrauterine hCG injection significantly increased rates of biochemical, clinical and ongoing pregnancy compared with controls. There were no between-group differences in implantation or miscarriage rates.

Conclusion: Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer.

Keywords: Intrauterine injection; embryo transfer; endometrial infusion; hCG; human chorionic gonadotropin; intracytoplasmic sperm injection; in vitro fertilization; meta-analysis.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Abortion, Spontaneous / epidemiology
  • Chorionic Gonadotropin / administration & dosage*
  • Chorionic Gonadotropin / pharmacology*
  • Drug Administration Routes
  • Embryo Implantation / drug effects
  • Embryo Transfer*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Rate
  • Reproductive Techniques, Assisted*
  • Sperm Injections, Intracytoplasmic
  • Treatment Outcome

Substances

  • Chorionic Gonadotropin