Objectives: A systematic review and meta-analysis to evaluate the effect of human chorionic gonadotropin (hCG) intrauterine injection before embryo transfer on the outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Methods: Searches of PubMed®, EMBASE®, EBSCO, Web of Science®, SCOPUS® and Cochrane Central Register of Controlled Trials were conducted to retrieve relevant randomized controlled trials (RCTs). Data were extracted and analysed.
Results: The meta-analysis included five RCTs (hCG group n = 680; control group n = 707). Intrauterine hCG injection significantly increased rates of biochemical, clinical and ongoing pregnancy compared with controls. There were no between-group differences in implantation or miscarriage rates.
Conclusion: Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer.
Keywords: Intrauterine injection; embryo transfer; endometrial infusion; hCG; human chorionic gonadotropin; intracytoplasmic sperm injection; in vitro fertilization; meta-analysis.
© The Author(s) 2015.