Collagen Turnover in Wound Repair--A Macrophage Connection

Liisa M Nissinen; Veli-Matti Kähäri

doi:10.1038/jid.2015.246

Collagen Turnover in Wound Repair--A Macrophage Connection

J Invest Dermatol. 2015 Oct;135(10):2350-2352. doi: 10.1038/jid.2015.246.

Authors

Liisa M Nissinen¹, Veli-Matti Kähäri²

Affiliations

¹ Department of Dermatology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland.
² Department of Dermatology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. Electronic address: veli-matti.kahari@utu.fi.

PMID: 26358383
DOI: 10.1038/jid.2015.246

Abstract

In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.

Publication types

Comment

MeSH terms

Animals
Collagenases / metabolism*
Female
Humans
Male
Matrix Metalloproteinase 10 / metabolism*
Skin / metabolism*
Wounds and Injuries / enzymology*

Substances

Collagenases
Matrix Metalloproteinase 10