Facile fabrication of bactericidal and antifouling switchable chitosan wound dressing through a 'click'-type interfacial reaction

Xianghong Wang; Shuaishuai Yuan; Yu Guo; Dean Shi; Tao Jiang; Shunjie Yan; Jiao Ma; Hengchong Shi; Shifang Luan; Jinghua Yin

doi:10.1016/j.colsurfb.2015.08.051

Facile fabrication of bactericidal and antifouling switchable chitosan wound dressing through a 'click'-type interfacial reaction

Colloids Surf B Biointerfaces. 2015 Dec 1:136:7-13. doi: 10.1016/j.colsurfb.2015.08.051. Epub 2015 Sep 5.

Authors

Xianghong Wang¹, Shuaishuai Yuan², Yu Guo³, Dean Shi⁴, Tao Jiang⁵, Shunjie Yan², Jiao Ma², Hengchong Shi², Shifang Luan⁶, Jinghua Yin⁷

Affiliations

¹ Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China; State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
² State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
³ Jilin Province People's Hospital, Changchun 130021, PR China.
⁴ Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China. Electronic address: deanshi2012@yahoo.com.
⁵ Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, PR China.
⁶ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: sfluan@ciac.ac.cn.
⁷ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: yinjh@ciac.ac.cn.

PMID: 26350800
DOI: 10.1016/j.colsurfb.2015.08.051

Abstract

A facile approach to functionalize chitosan (CS) non-woven surface with the bactericidal and antifouling switchable moieties is presented. Azlactone-cationic carboxybetaine ester copolymer was firstly prepared, then chemically attached onto CS non-woven surface through the fast and efficient 'click'-type interfacial reaction between CS primary amines and azlactone moieties. The CS non-woven surface functionalized with cationic carboxybetaine esters is able to kill bacteria effectively. Upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resulting zwitterionic surface can further prevent the attachment of proteins, platelets, erythrocytes and bacteria. This CS non-woven that switches from bactericidal performance during storage to antifouling property before its service has great potential in wound dressing applications.

Keywords: Antifouling; Azlactone-carboxybetaine ester copolymer; Bactericidal; Chitosan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Bandages*
Chitosan*
Microscopy, Electron, Scanning
Proton Magnetic Resonance Spectroscopy

Substances

Anti-Bacterial Agents
Chitosan