Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth

Wei Jia; Yan-Yan Bai; Zhong Zhang; Na Feng; Jie Feng; Meng-Qiu Yan; Li-Na Zhu; Xin-Cheng Jia; Ming-Dao Wang; Jing-song Zhang; Hua Fan

doi:10.1615/intjmedmushrooms.v17.i6.40

Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth

Int J Med Mushrooms. 2015;17(6):533-40. doi: 10.1615/intjmedmushrooms.v17.i6.40.

Authors

Wei Jia¹, Yan-Yan Bai¹, Zhong Zhang¹, Na Feng², Jie Feng³, Meng-Qiu Yan³, Li-Na Zhu³, Xin-Cheng Jia⁴, Ming-Dao Wang⁴, Jing-song Zhang¹, Hua Fan⁵

Affiliations

¹ Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, National Engineering Research Center of Edible Fungi, National R&D Center for Edible Fungi.
² Insitute of Edible Fungi,Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization, Shanghai Key Laboratory of Agricultural Genetics and Breeding, China.
³ Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi; Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Shanghai, People's Republic of China.
⁴ College of Life Sciences, Henan Agricultural University, Zhengzhou, Henan, China.
⁵ Institut fur Laboratoriumsmedizin, Klinische Chemie, Charite Universitatsmedizin, Berlin, Germany.

PMID: 26349511
DOI: 10.1615/intjmedmushrooms.v17.i6.40

Abstract

A known compound, 5-(hydroxymethyl) furan-2-carbaldehyde, and a novel compound, 3-isobutyl-1-methoxy-4-(4'-(3-methylbut-2-enyloxy)phenyl)-1H-pyrrole-2,5-dione were isolated from spent broth from submerged cultures of Taiwanofungus camphoratus. Their structures were elucidated by nuclear magnetic resonance (1H, 13C, and 2D) and mass spectra. These compounds inhibited the proliferation of K562 and HepG2 tumor cells in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agaricales / growth & development*
Agaricales / metabolism*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Culture Media / chemistry*
Hepatocytes / drug effects
Hepatocytes / physiology
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry

Substances

Antineoplastic Agents
Culture Media