Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Hussain Gadelkarim Ahmed; Saleh Hussein Bensumaidea; Ibraheem M Ashankyty

doi:10.1186/s13027-015-0026-9

Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Infect Agent Cancer. 2015 Sep 7:10:29. doi: 10.1186/s13027-015-0026-9. eCollection 2015.

Authors

Hussain Gadelkarim Ahmed¹, Saleh Hussein Bensumaidea², Ibraheem M Ashankyty³

Affiliations

¹ Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Ha'il, Kingdom of Saudi Arabia ; Department of Pathology, College of Medicine, University of Ha'il, 2240 Hai'l, Kingdom of Saudi Arabia ; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan.
² Department of Pathology, College of Medicine, Hadhramout University of Science and Technology, Hadhramout, Yemen.
³ Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Ha'il, Kingdom of Saudi Arabia ; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Ha'il, Ha'il, Kingdom of Saudi Arabia.

Abstract

Background: Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer.

Methodology: A total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).

Results: Of the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %.

Conclusion: HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

Keywords: Cervical cancer; HPV31; HPV33; HPV35; HPV39; HPV45; Yemeni.