Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model

Junning Ma; Junwei Gao; Boru Hou; Jixing Liu; Sihua Chen; Guizhong Yan; Haijun Ren

Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model

Int J Clin Exp Pathol. 2015 Jul 1;8(7):7838-48. eCollection 2015.

Authors

Junning Ma¹, Junwei Gao¹, Boru Hou¹, Jixing Liu², Sihua Chen², Guizhong Yan², Haijun Ren¹

Affiliations

¹ Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China ; Lanzhou University Lanzhou 730000, Gansu Province, China.
² Department of Neurosurgery, Lanzhou University Second Hospital Lanzhou 730000, Gansu Province, China.

PMID: 26339348
PMCID: PMC4555676

Abstract

Stem cell-based therapy provides a promising approach for treat stroke. Neural stem cells isolated from mice hippocampus possessing the capacity of differentiate into neurons and astrocytes both in vitro and vivo. Here, we investigated the capability of neural stem cell transplantation in photothrombosis stroke model. Nissl staining revealed that the cortical infarct significantly decreased by 16.32% (Vehicle: 27.93le: an mm(3), n=6, NSC: 23.37le: ai mm(3), n=6, P<0.05) in the NSC group compared with the vehicle. More over transplantation of neural stem cells significantly (P<0.01) improved neurological performance compared with vehicle. These results indicate that transplantation of neural stem cell is an effective therapy in ischemic stroke.

Keywords: Neural stem cell; functional recovery; ischemic stroke; photothrombotic model; transplantation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Astrocytes / metabolism
Disease Models, Animal
Humans
Male
Mice
Neural Stem Cells / transplantation*
Neurons / metabolism
Recovery of Function
Stem Cell Transplantation / methods*
Stroke / complications
Stroke / pathology
Stroke / therapy