[The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium]

V I Borutaĭte; V Iu Mildazhene; L I Ivanovene; B N Kholodenko; A I Toleĭkis; A K Prashkiavichius

[The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium]

Biokhimiia. 1989 Dec;54(12):1947-51.

[Article in Russian]

Authors

V I Borutaĭte, V Iu Mildazhene, L I Ivanovene, B N Kholodenko, A I Toleĭkis, A K Prashkiavichius

PMID: 2633800

Abstract

The effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria in different metabolic states was studied. Acyl-CoA inhibited O2 consumption by 11% in State 4 and by 6% in State 3. However, the effect of acyl-CoA was more pronounced (20%) in the intermediate state of respiration between State 4 and State 3. The data obtained suggest that acyl-CoA can regulate oxidative phosphorylation in heart mitochondria in vivo.

Publication types

English Abstract

MeSH terms

Acyl Coenzyme A / metabolism*
Adenosine Diphosphate / metabolism
Animals
Creatine Kinase / metabolism
Kinetics
Mitochondria, Heart / enzymology
Mitochondria, Heart / metabolism*
Myocardium / enzymology
Myocardium / metabolism*
Oxidative Phosphorylation*
Oxygen Consumption
Rabbits

Substances

Acyl Coenzyme A
Adenosine Diphosphate
Creatine Kinase