Pinosylvin Inhibits TRPA1-Induced Calcium Influx In Vitro and TRPA1-Mediated Acute Paw Inflammation In Vivo

Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):238-42. doi: 10.1111/bcpt.12485. Epub 2015 Oct 7.

Authors

Lauri J Moilanen¹, Mari Hämäläinen¹, Lauri Lehtimäki², Riina M Nieminen¹, Katsuhiko Muraki³, Eeva Moilanen¹

Affiliations

¹ The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
² Department of Respiratory Medicine, University of Tampere School of Medicine and Allergy Centre, Tampere University Hospital, Tampere, Finland.
³ Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, Nagoya, Japan.

PMID: 26335783
DOI: 10.1111/bcpt.12485

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Animals
Calcium / metabolism*
Calcium Channels / metabolism*
HEK293 Cells
Humans
Inflammation / chemically induced
Inflammation / drug therapy*
Inflammation / genetics
Inhibitory Concentration 50
Isothiocyanates / toxicity
Male
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins / antagonists & inhibitors
Nerve Tissue Proteins / metabolism*
Stilbenes / pharmacology*
TRPA1 Cation Channel
Transient Receptor Potential Channels / antagonists & inhibitors
Transient Receptor Potential Channels / metabolism*

Substances

Calcium Channels
Isothiocyanates
Nerve Tissue Proteins
Stilbenes
TRPA1 Cation Channel
TRPA1 protein, human
Transient Receptor Potential Channels
Trpa1 protein, mouse
pinosylvin
allyl isothiocyanate
Calcium