Overdose the addiction--A new strategy to ablate cancer cells

Sci China Life Sci. 2015 Nov;58(11):1169-70. doi: 10.1007/s11427-015-4921-5. Epub 2015 Sep 2.

Author

Lei Li¹

Affiliation

¹ Department of Experimental Radiation Oncology, Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. leili@mdanderson.org.

PMID: 26335741
DOI: 10.1007/s11427-015-4921-5

No abstract available

MeSH terms

Animals
Cell Line, Tumor
Cell Survival / drug effects
Cyclohexanones / pharmacology*
Female
HEK293 Cells
HeLa Cells
Humans
Immunoblotting
MCF-7 Cells
Mice, Nude
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / prevention & control*
Nuclear Receptor Coactivator 1 / genetics
Nuclear Receptor Coactivator 1 / metabolism*
Nuclear Receptor Coactivator 2 / genetics
Nuclear Receptor Coactivator 2 / metabolism*
Nuclear Receptor Coactivator 3 / genetics
Nuclear Receptor Coactivator 3 / metabolism*
Pyridines / pharmacology*
Reverse Transcriptase Polymerase Chain Reaction
Tumor Burden / drug effects
Xenograft Model Antitumor Assays

Substances

4-ethyl-2,6-bispyridin-3-ylmethylenecyclohexanone
Cyclohexanones
Nuclear Receptor Coactivator 2
Pyridines
Nuclear Receptor Coactivator 1
Nuclear Receptor Coactivator 3