Abstract
Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Diterpenes, Clerodane / chemistry
-
Diterpenes, Clerodane / isolation & purification*
-
Diterpenes, Clerodane / pharmacology*
-
Inhibitory Concentration 50
-
Lipopolysaccharides / pharmacology*
-
Macrophages / drug effects
-
Molecular Structure
-
Nitric Oxide / biosynthesis*
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Components, Aerial / chemistry
-
Scutellaria / chemistry*
Substances
-
Diterpenes, Clerodane
-
Lipopolysaccharides
-
scutebatin A
-
scutebatin B
-
scutebatin C
-
Nitric Oxide