SRFBP1, an Additional Player in HCV Entry

Lucie Fénéant; Laurence Cocquerel

doi:10.1016/j.tim.2015.08.003

SRFBP1, an Additional Player in HCV Entry

Trends Microbiol. 2015 Oct;23(10):590-593. doi: 10.1016/j.tim.2015.08.003. Epub 2015 Aug 26.

Authors

Lucie Fénéant¹, Laurence Cocquerel²

Affiliations

¹ Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL -Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
² Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL -Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France. Electronic address: laurence.cocquerel@ibl.cnrs.fr.

PMID: 26319372
DOI: 10.1016/j.tim.2015.08.003

Abstract

The tetraspanin CD81 dynamics and interactions with other proteins are essential for hepatitis C virus (HCV) entry. Recently, Gerold and collaborators used a proteomic approach and found the serum response factor binding protein 1 (SRFBP1) to be involved in a post-fusion entry process by interacting with CD81 upon HCV infection.

Keywords: Hepatitis C Virus; SRFBP1; entry factor; protein-protein interactions; proteomics; the tetraspanin CD81.

Publication types

Comment

MeSH terms

Hepacivirus / physiology*
Humans
Proteomics*
Transcription Factors / metabolism*
Virus Internalization*

Substances

Transcription Factors