Delayed reactivation of chronic infantile neurologic, cutaneous, articular syndrome (CINCA) in a patient with somatic mosaicism of CIAS1/NLRP3 gene after withdrawal of anti-IL-1 beta therapy

Clin Exp Rheumatol. 2015 Sep-Oct;33(5):766. Epub 2015 Aug 27.

Authors

Giulia Paloni¹, Serena Pastore¹, Alberto Tommasini¹, Loredana Lepore², Andrea Taddio³

Affiliations

¹ Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
² University of Trieste, Trieste, Italy.
³ Institute for Maternal and Child Health, IRCCS Burlo Garofolo, and University of Trieste, Trieste, Italy.

PMID: 26316056

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized
Carrier Proteins / genetics*
Cryopyrin-Associated Periodic Syndromes / diagnosis
Cryopyrin-Associated Periodic Syndromes / drug therapy*
Cryopyrin-Associated Periodic Syndromes / genetics
Cryopyrin-Associated Periodic Syndromes / immunology
Drug Administration Schedule
Female
Genetic Predisposition to Disease
Humans
Immunosuppressive Agents / administration & dosage*
Interleukin 1 Receptor Antagonist Protein / administration & dosage*
Interleukin-1beta / antagonists & inhibitors*
Interleukin-1beta / immunology
Mosaicism*
NLR Family, Pyrin Domain-Containing 3 Protein
Phenotype
Recurrence
Remission Induction
Time Factors
Treatment Outcome
Young Adult

Substances

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Carrier Proteins
IL1B protein, human
Immunosuppressive Agents
Interleukin 1 Receptor Antagonist Protein
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human
canakinumab