Deciphering the biochemistry and identifying biomarkers to multiple sclerosis

Daniel Martins-de-Souza; Alessandro S Farias

doi:10.1002/pmic.201500332

Deciphering the biochemistry and identifying biomarkers to multiple sclerosis

Proteomics. 2015 Oct;15(19):3281-2. doi: 10.1002/pmic.201500332.

Authors

Daniel Martins-de-Souza^{1

2}, Alessandro S Farias^{1

3}

Affiliations

¹ UNICAMP's Neurobiology Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
² Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
³ Neuroimmunology Unit, Department of Genetics, Evolution, and Bioagents, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

PMID: 26314682
DOI: 10.1002/pmic.201500332

Abstract

Multiple sclerosis is an idiopathic demyelinating disease of the CNS. Despite being extensively studied during the last decades, many molecular aspects of the disease are still to be elucidated. Moreover, biomarkers for treatment and early diagnosis are major issues to be tackled. In this edition of Kroksveen et al. (Proteomics 2015, 15, 3361-3369) present biomarker candidates for the early detection of multiple sclerosis. Despite the need for validation in larger sets of samples, this dataset contributes to resolve open questions associated to multiple sclerosis.

Keywords: Biomarkers; Cerebrospinal fluid; Multiple sclerosis; Quantitative MS; Secretogranin-1.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromogranin B / cerebrospinal fluid*
Female
Humans
Male
Multiple Sclerosis / cerebrospinal fluid*

Substances

Chromogranin B