Subtype associations with HIV-associated neurocognitive disorder in China

J Neurovirol. 2016 Apr;22(2):246-50. doi: 10.1007/s13365-015-0377-4. Epub 2015 Aug 26.

Abstract

Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4(+) counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4(+) counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.

Keywords: CD4 nadir; HIV subtype; HIV-associated; Neurocognitive disorders; Neurocognitive impairment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • China
  • Cognitive Dysfunction / complications
  • Cognitive Dysfunction / drug therapy*
  • Cognitive Dysfunction / physiopathology
  • Cognitive Dysfunction / virology
  • Cohort Studies
  • Executive Function
  • Female
  • Genotype*
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / physiopathology
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / drug effects
  • HIV-1 / genetics*
  • Humans
  • Male
  • Neuropsychological Tests
  • Psychomotor Performance
  • Risk Factors
  • Viral Load / drug effects

Substances

  • Anti-HIV Agents