Keeping Oxidative Metabolism on Time: Mitochondria as an Autonomous Redox Pacemaker Animated by H2O2 and Peroxiredoxin

Michel B Toledano; Agnès Delaunay-Moisan

doi:10.1016/j.molcel.2015.08.003

Keeping Oxidative Metabolism on Time: Mitochondria as an Autonomous Redox Pacemaker Animated by H2O2 and Peroxiredoxin

Mol Cell. 2015 Aug 20;59(4):517-9. doi: 10.1016/j.molcel.2015.08.003.

Authors

Michel B Toledano¹, Agnès Delaunay-Moisan²

Affiliations

¹ Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, France. Electronic address: michel.toledano@cea.fr.
² Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, France.

PMID: 26295958
DOI: 10.1016/j.molcel.2015.08.003

Abstract

In this issue of Molecular Cell, Kil et al. (2015) provide evidence for self-sustained circadian oscillations of the hyperoxidation of the mitochondrial Peroxiredoxin, PrxIII, and cytosolic release of mitochondrial H2O2, which might constitute one biochemical output coupling metabolic changes and transcriptional-based core clocks.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Circadian Rhythm*
Humans
Mitochondria / enzymology*
Oxidoreductases Acting on Sulfur Group Donors / metabolism*

Substances

Oxidoreductases Acting on Sulfur Group Donors