The potential of Information and Communication Technologies to improve the overall quality of life of all citizens cannot be underestimated. In particular, in the context of Ambient Intelligent environments, technological developments provide a great opportunity for the integration and the improvement of quality of life of people from vulnerable groups (patients, elderly, people with disabilities). In this context, the paper presents the aims, objectives and preliminary results of a National research project in Greece, named KRIPIS "Quality of Life", implemented by three research Institutes of FORTH, targeting post-heart attack elderly patients at their home environments.