Recurrent Methicillin-Resistant Staphylococcus aureus Cutaneous Abscesses and Selection of Reduced Chlorhexidine Susceptibility during Chlorhexidine Use

J Clin Microbiol. 2015 Nov;53(11):3677-82. doi: 10.1128/JCM.01771-15. Epub 2015 Aug 19.

Abstract

We describe the selection of reduced chlorhexidine susceptibility during chlorhexidine use in a patient with two episodes of cutaneous USA300 methicillin-resistant Staphylococcus aureus abscess. The second clinical isolate harbors a novel plasmid that encodes the QacA efflux pump. Greater use of chlorhexidine for disease prevention warrants surveillance for resistance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abscess / diagnosis
  • Abscess / drug therapy*
  • Abscess / microbiology
  • Adolescent
  • Bacterial Proteins / genetics*
  • Chlorhexidine / therapeutic use
  • Disinfectants / therapeutic use*
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Male
  • Membrane Transport Proteins / genetics*
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Methicillin-Resistant Staphylococcus aureus / genetics
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Microbial Sensitivity Tests
  • Military Personnel
  • Molecular Sequence Data
  • Plasmids / genetics
  • Recurrence
  • Selection, Genetic / drug effects
  • Selection, Genetic / genetics
  • Skin Diseases, Bacterial / diagnosis
  • Skin Diseases, Bacterial / drug therapy*
  • Skin Diseases, Bacterial / microbiology
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Surveys and Questionnaires

Substances

  • Bacterial Proteins
  • Disinfectants
  • Membrane Transport Proteins
  • qacA protein, Staphylococcus aureus
  • Chlorhexidine