Creating Long-Lived Spin States at Variable Magnetic Field by Means of Photochemically Induced Dynamic Nuclear Polarization

Alexey S Kiryutin; Sergey E Korchak; Konstantin L Ivanov; Alexandra V Yurkovskaya; Hans-Martin Vieth

doi:10.1021/jz3005046

Creating Long-Lived Spin States at Variable Magnetic Field by Means of Photochemically Induced Dynamic Nuclear Polarization

J Phys Chem Lett. 2012 Jul 5;3(13):1814-9. doi: 10.1021/jz3005046. Epub 2012 Jun 22.

Authors

Alexey S Kiryutin^{1

2}, Sergey E Korchak^{1

3}, Konstantin L Ivanov^{2

4}, Alexandra V Yurkovskaya^{2

4}, Hans-Martin Vieth¹

Affiliations

¹ †Institute of Experimental Physics, Freie Universität Berlin, Arnimallee14, D-14195 Berlin, Germany.
² ‡International Tomography Center, Institutskaya 3a, 630090, Novosibirsk, Russia.
³ §Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, D-10587 Berlin, Germany.
⁴ ∥Novosibirsk State University, Pirogova 2, 630090, Novosibirsk, Russia.

PMID: 26291865
DOI: 10.1021/jz3005046

Abstract

We have shown that long-lived spin states (LLS) can be selectively populated by photogenerated chemically induced dynamic nuclear polarization (CIDNP) over a wide range of magnetic fields. Relaxation times of LLS of the β-CH2 protons in N-acetyl histidine and partially deuterated histidine have been measured. Our experiments demonstrate that CIDNP enables creating LLS in the amino acid in a field range of up to a few Tesla and that their lifetimes can be 45 times longer than T1. The advantage of the method is thus two-fold: it allows one to accumulate high levels of spin hyperpolarization and to preserve them for periods of time far exceeding T1. Therefore, photo-CIDNP is a technique suitable for creating long-lived spin order in biologically relevant molecules.

Keywords: NMR; hyperpolarization; long-lived spin states; photo-CIDNP.