MDA-9/Syntenin Control

Julie V Philley; Anbarasu Kannan; Santanu Dasgupta

doi:10.1002/jcp.25136

MDA-9/Syntenin Control

J Cell Physiol. 2016 Mar;231(3):545-50. doi: 10.1002/jcp.25136. Epub 2015 Oct 7.

Authors

Julie V Philley¹, Anbarasu Kannan², Santanu Dasgupta²

Affiliations

¹ Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, Texas.
² Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.

PMID: 26291527
DOI: 10.1002/jcp.25136

Abstract

MDA-9/Syntenin is a small PDZ domain containing scaffolding protein with diverse array of functions regulating membrane trafficking, cell adhesion, neural, and synaptic development, ubiquitination, and exosome biogenesis. An appreciable number of studies also established a pivotal role of MDA-9/Syntenin in cancer development and progression. In this review, we will discuss the dynamic role of MDA-9/Syntenin in regulating normal and abnormal fate of various cellular processes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Adhesion / physiology*
Cell Movement / physiology*
Humans
Neoplasms / metabolism*
Protein Binding / physiology
Syntenins / metabolism*

Substances

SDCBP protein, human
Syntenins