Eco-Friendly Synthesis of a New Class of Pyridinium-Based Ionic Liquids with Attractive Antimicrobial Activity

Molecules. 2015 Aug 14;20(8):14936-49. doi: 10.3390/molecules200814936.

Abstract

The present study reports a green synthesis of a new family of ionic liquids (ILs) based on functionalized 4-dimethylaminopyridinium derivatives. The structures of 23 newly synthesized ILs (2-24) were confirmed by FT-IR, (1)H-, (13)C-, (11)B-, (19)F-, and (31)P-NMR spectroscopy and mass spectrometry. The antimicrobial activity of all novel ILs was tested against a panel of bacteria and fungi. The results prove that all tested ILs are effective antibacterial and antifungal agents, especially 4-(dimethylamino)-1-(4-phenoxybutyl) pyridinium derivatives 5 and 19.

Keywords: antimicrobial activity; eco-friendly synthesis; ionic liquid; ultrasound irradiation.

MeSH terms

  • Alkylation
  • Anions
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects
  • Fungi / drug effects
  • Green Chemistry Technology / methods*
  • Ionic Liquids / chemical synthesis*
  • Ionic Liquids / pharmacology*
  • Microbial Sensitivity Tests
  • Pyridinium Compounds / chemical synthesis*
  • Pyridinium Compounds / pharmacology*
  • Ultrasonics

Substances

  • Anions
  • Anti-Infective Agents
  • Ionic Liquids
  • Pyridinium Compounds