Animal models of erectile dysfunction

J Pharmacol Toxicol Methods. 2015 Nov-Dec:76:43-54. doi: 10.1016/j.vascn.2015.07.013. Epub 2015 Aug 14.

Abstract

Erectile dysfunction (ED) is a prevalent male sexual dysfunction with profound adverse effects on the physical and the psychosocial health of men and, subsequently, on their partners. The expanded use of various types of rodent models has produced some advances in the study of ED, and neurophysiological studies using various animal models have provided important insights into human sexual dysfunction. At present, animal models play a key role in exploring and screening novel drugs designed to treat ED.

Keywords: Animal models; Drug targets; Erectile dysfunction; Sexual dysfunction.

Publication types

  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / physiopathology
  • Disease Models, Animal*
  • Endothelium, Vascular / physiopathology
  • Erectile Dysfunction* / drug therapy
  • Erectile Dysfunction* / etiology
  • Erectile Dysfunction* / psychology
  • Humans
  • Male
  • Orchiectomy
  • Penis / blood supply
  • Penis / innervation
  • Smoking / adverse effects
  • Spinal Cord Injuries / complications
  • Stress, Psychological / complications