BNCT treatment planning for superficial and deep-seated tumors: Experience from clinical trial of recurrent head and neck cancer at THOR

Yen-Wan Hsueh Liu; Chih-Ting Chang; Lan-Yun Yeh; Ling-Wei Wang; Tzung-Yi Lin

doi:10.1016/j.apradiso.2015.08.002

BNCT treatment planning for superficial and deep-seated tumors: Experience from clinical trial of recurrent head and neck cancer at THOR

Appl Radiat Isot. 2015 Dec:106:121-4. doi: 10.1016/j.apradiso.2015.08.002. Epub 2015 Aug 5.

Authors

Yen-Wan Hsueh Liu¹, Chih-Ting Chang², Lan-Yun Yeh², Ling-Wei Wang³, Tzung-Yi Lin²

Affiliations

¹ Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan, ROC. Electronic address: ywhliu@gmail.com.
² Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan, ROC.
³ Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

PMID: 26278349
DOI: 10.1016/j.apradiso.2015.08.002

Abstract

Under the collaboration between National Tsing Hua University and Taipei Veterans General Hospital, clinical trial of recurrent head-and-neck cancer by Boron neutron capture therapy at Tsing Hua open-pool reactor started on August 11, 2010. Up to January 2014, 17 patients were treated. Based on the treatment planning experiences of clinical trials using in-house designed THORplan, different setups should be used for superficial and deep-seated tumors. Superficial tumor treatment gains benefits from the use of patient collimator, while direct irradiation is a better choice for deep-seated tumor.

Keywords: Boron neutron capture therapy; Head and neck cancer; Treatment planning.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Boron Neutron Capture Therapy*
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / radiotherapy*
Humans
Neoplasm Recurrence, Local
Radiotherapy Planning, Computer-Assisted / methods*