Abstract
A 49-year-old man was admitted to a hospital with chest pain and polyarthralgia. Chest radiography showed abnormal findings, and chest computed tomography showed a mass in the right lung. A transbronchial lung biopsy led to a diagnosis of anaplastic lymphoma kinase (ALK)-positive adenocarcinoma. Bone scintigraphy revealed bilateral symmetrical accumulations of (99m)Technetium complexes in the long bones, suggesting co-existing hypertrophic pulmonary osteoarthropathy (HPO). The patient underwent four courses of chemotherapy with cisplatin plus pemetrexed, which led to decreased (99m)Technetium accumulations in the long bones. To the best of our knowledge, this is the first reported case of HPO associated with ALK-positive lung cancer.
MeSH terms
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Adenocarcinoma / complications
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Adenocarcinoma / diagnostic imaging
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Adenocarcinoma / pathology*
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Anaplastic Lymphoma Kinase
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Bone and Bones / diagnostic imaging
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Bone and Bones / pathology*
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Chest Pain / etiology*
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Humans
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Lung Neoplasms / complications
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / pathology*
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Male
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Middle Aged
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Osteoarthropathy, Secondary Hypertrophic / diagnostic imaging
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Osteoarthropathy, Secondary Hypertrophic / etiology*
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Osteoarthropathy, Secondary Hypertrophic / pathology
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Positron-Emission Tomography / methods
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Receptor Protein-Tyrosine Kinases / analysis*
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Technetium Tc 99m Medronate
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Tomography, X-Ray Computed
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Treatment Outcome
Substances
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ALK protein, human
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Anaplastic Lymphoma Kinase
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Receptor Protein-Tyrosine Kinases
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Technetium Tc 99m Medronate