A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

Jian-Yue Jin; Bo Zhao; Joseph M Kaminski; Ning Wen; Yimei Huang; John Vender; Indrin J Chetty; Feng-Ming Spring Kong

doi:10.1016/j.radonc.2015.07.047

A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

Radiother Oncol. 2015 Dec;117(3):483-6. doi: 10.1016/j.radonc.2015.07.047. Epub 2015 Aug 12.

Authors

Jian-Yue Jin¹, Bo Zhao², Joseph M Kaminski³, Ning Wen², Yimei Huang², John Vender⁴, Indrin J Chetty², Feng-Ming Spring Kong³

Affiliations

¹ Radiation Oncology, Georgia Regents University, Augusta, United States. Electronic address: jjin@gru.edu.
² Radiation Oncology, Henry Ford Hospital, Detroit, United States.
³ Radiation Oncology, Georgia Regents University, Augusta, United States.
⁴ Neurosurgery, Georgia Regents University, Augusta, United States.

PMID: 26277434
DOI: 10.1016/j.radonc.2015.07.047

Abstract

This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.

Keywords: Ablative radiation; Film dosimetry; Grid therapy; Immune-response; Spatially fractionated radiotherapy.

MeSH terms

Dose Fractionation, Radiation*
Humans
Radiotherapy Planning, Computer-Assisted / methods
Radiotherapy, Conformal / methods*