Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

Molecules. 2015 Aug 12;20(8):14565-75. doi: 10.3390/molecules200814565.

Abstract

Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.

Keywords: Bruguiera gymnorrhiza; antiviral; cyclohexylideneacetonitrile derivative.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetonitriles / chemistry*
  • Acetonitriles / isolation & purification
  • Acetonitriles / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology
  • Cell Line, Tumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Hepatitis B virus / drug effects
  • Humans
  • Hypocotyl / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Rhizophoraceae / chemistry*
  • Wetlands

Substances

  • Acetonitriles
  • Benzofurans
  • Glycosides
  • Plant Extracts
  • menisdaurilide
  • menisdaurin